Open AccessQuantitative Capillary Supercritical Fluid Chromatography and Supercritical Fluid Extraction of Basic Drugs of Abuse
Author(s) -
Patrick Edder,
W. Haerdi,
JeanLuc Veuthey,
Christian Staub
Publication year - 1992
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1992.141
Subject(s) - chromatography , supercritical fluid , supercritical fluid extraction , supercritical fluid chromatography , extraction (chemistry) , chemistry , aqueous solution , solvent , volumetric flow rate , capillary action , drugs of abuse , gas chromatography , materials science , drug , organic chemistry , pharmacology , medicine , physics , quantum mechanics , composite material
Capillary SFC of basic drugs of abuse have been studied using two different columns, and the results were compared with GC. These results have proved the ability of supercritical CO2 to solubilize and extract basic drugs of interest. A novel restrictor has been used to control precisely the flow rate through the extraction cell over a long period of time. Optimal conditions for quantitative recoveries of aqueous morphine adsorbated on C18 silica by SFE has been determined. Recoveries of 100% with a variation of 2% was obtained with an extraction time of 25 min. The influence of the pressure, solvent modifier, and flow rate of extraction fluid on the extraction efficiency was determined. These conditions were also found to be applicable for extracting other drugs of abuse.