Open AccessRadiation Damage in Carnidazole: a Single Crystal EPR Study
Author(s) -
Théo Berclaz,
Gérald Bernardinelli,
Michel Geoffroy,
N. Rajalakshmi
Publication year - 1992
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.1992.130
Subject(s) - electron paramagnetic resonance , anhydrous , moiety , single crystal , radical , molecule , context (archaeology) , chemistry , crystal (programming language) , crystallography , irradiation , photochemistry , materials science , nuclear magnetic resonance , stereochemistry , organic chemistry , physics , paleontology , computer science , nuclear physics , programming language , biology
Single crystals of hydrated and anhydrous carnidazole have been subjected to X-irradiation at 77 K and studied by EPR. The determination of the EPR tensors shows that NO2, sulfur-centered radicals as well as a radical pair can be generated from this molecule; it appears that the species trapped at 77 K are not the same in the hydrated and in the anhydrous crystal. The results are discussed in the context of the radiosensitizing action of molecules containing a 5-nitroimidazole moiety.