LC for Sample Preparation in Coupled LC-GC: A Review

In chromatographic trace analysis, most of the working time is spent in preparing the sample; the methods involved are largely inefficient, often rather primitive. (HP)LC could replace a good part of this pre-separation, clean-up or sample enrichment work. It offers high separation efficiency, a wide range of selectivities, and accurate control through on-line detection. LC work is reviewed that is related to on-line LC-GC, showing the wealth of possibilities available for LC sample preparation. The present problems are discussed, hoping to motivate colleagues getting involved in the development of advanced sample preparation techniques.