Open AccessUnravelling the Potential of Natural Products – Biological Profiling of Extracts and New Molecules
Author(s) -
Matthias Hamburger
Publication year - 2006
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942906777675227
Subject(s) - natural product , profiling (computer programming) , computational biology , natural product research , in vivo , mechanism (biology) , biochemical engineering , biology , chemistry , in vitro , microbiology and biotechnology , biological activity , computer science , pharmacognosy , biochemistry , engineering , operating system , philosophy , epistemology
Natural products are highly useful as sources of drugs and as tools for fundamental biomedical research. Phytomedicines based on medicinal plants and herbal extracts are used worldwide. Using three examples from our lab, we have shown different approaches to explore the biological and pharmacological properties of herbal extracts and new natural product leads. Our emphasis has been on global effects and multiple rather than single targets, whereby cell- and mechanism-based in vitro assays, in vivo pharmacology, cell biology and transcriptional profiling were employed.