Open AccessA Thorough Training in Modern Drug Design
Author(s) -
Angelo Vedani,
Oliver Schwardt,
Said Rabbani,
Beat Ernst
Publication year - 2006
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942906777675137
Subject(s) - drug , in silico , computer science , class (philosophy) , bradykinin , pharmacy , pharmacology , computational biology , medical physics , chemistry , medicine , receptor , artificial intelligence , biology , biochemistry , family medicine , gene
The laboratory class Modern Drug Design at the Department of Pharmacy of the University of Basel offers the students a thorough training in modern drug design. First, antagonists for the Bradykinin B2 receptor are designed using state-of-the-art modelling techniques, followed by solid-phase synthesis of the most potent candidates identified in silico. Thereafter, their activity is determined by a fluorometric assay. By communicating the results to the next class of students, a feedback loop is completed, thereby allowing the design strategy to be improved.