Open AccessMinireview: Bacterial Sialyltransferases for Carbohydrate Synthesis
Author(s) -
Oliver Schwardt,
Tamara Visekruna,
Said Rabbani,
Beat Ernst
Publication year - 2006
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942906777674787
Subject(s) - glycosyl , substrate specificity , chemistry , substrate (aquarium) , biochemistry , enzyme , sialyltransferase , carbohydrate synthesis , bacteria , combinatorial chemistry , biology , ecology , genetics
Sialylation catalyzed by sialyltransferases is one of the most interesting enzymatic glycosyl transfer reactions, since chemical sialylations usually give only low yields and lead to poor stereoselectivities. In the last decade, several bacterial sialyltransferases were identified and found to exhibit broader substrate specificity than their mammalian counterparts. This suggests the potential usefulness of bacterial sialyltransferases in chemo-enzymatic synthesis of natural and non-natural sialooligosaccharides.