Open AccessFormulation Optimization in a University Hospital: The Example of Pediatric Solutions of the ACE Inhibitor Captopril
Author(s) -
Markoulina BergerGryllaki,
G. Podilsky,
Nicolas Widmer,
Stephane Gloor,
Bernard Testa,
André Pannatier
Publication year - 2005
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942905777676362
Subject(s) - captopril , chromatography , medicine , drug , pediatric hospital , pharmacology , high performance liquid chromatography , dosage form , chemistry , pediatrics , blood pressure
Many major drugs are not available in pediatric form. As a result, hospital pharmacists are often requested to provide the medical staff with liquid formulations for individualized dosage and easy administration to newborn and young patients. Such in-house formulations must of course fulfil stringent criteria of purity and stability. This paper reports the development of a liquid solution of captopril for pediatric use. A specific HPLC-UV method was developed. A number of formulations described in the literature as affording one-month stability were examined and found wanting. A simple solution of the drug (1 mg/ml) in purified water containing 0.1% EDTA-Na proved chemically and microbiologically stable at room temperature for two years.