Open AccessTargeting Posttranslational Modifications – Perspectives for Biocatalyst Engineering
Author(s) -
Beate Pscheidt,
Robert Weis,
Anton Glieder
Publication year - 2005
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942905777675679
Subject(s) - posttranslational modification , biocatalysis , rendering (computer graphics) , computational biology , biochemical engineering , protein engineering , computer science , enzyme , chemistry , biochemistry , biology , engineering , artificial intelligence , catalysis , ionic liquid
Engineering posttranslational modifications is of great importance in biomedical research. Recent advances in the field of biocatalyst engineering expanded the strategy of targeting posttranslational modifications to a novel research field, i.e. rendering the particular enzyme more efficient for the desired biocatalytic conversion. Thus enzymes could be trimmed to higher fitness for technical applications e.g. by improved activity and/or prolonged life-time. Furthermore, bottlenecks during enzyme expression caused by posttranslational processing in the cell can be overcome. Focusing especially on recent approaches in our laboratory, this article presents strategies for targeted manipulations of selected posttranslational modifications.