Open AccessDNA Mimics Containing Non-Nucleosidic Base Surrogates
Author(s) -
Simon M. Langenegger,
Gapian Bianké,
Rolf Tona,
Robert Häner
Publication year - 2005
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942905777675651
Subject(s) - nucleic acid , dna , nucleotide , computational biology , base (topology) , combinatorial chemistry , chemistry , reagent , computer science , biology , biochemistry , organic chemistry , gene , mathematics , mathematical analysis
Chemically modified nucleic acids find widespread use as tools in research, as diagnostic reagents and as pharmaceutical compounds. While the major efforts in the past concentrated on the generation of sugar-based nucleotide analogues, the potential of non-nucleosidic and non-hydrogen bonding building blocks is largely untouched to date. Such derivatives may have an impact in the fields of materials and genetic research. In this paper, some recent findings of our work in this area are highlighted.