Open AccessEncoded Self-Assembling Chemical Libraries
Author(s) -
Samu Melkko,
Jens Sobek,
Greta Guarda,
Jörg Scheuermann,
Christoph E. Dumelin,
Dario Neri
Publication year - 2005
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942905777675525
Subject(s) - oligonucleotide , moiety , chemical biology , sequence (biology) , combinatorial chemistry , nanotechnology , chemistry , drug discovery , computational biology , dna , computer science , stereochemistry , materials science , biochemistry , biology
The display of chemical moieties at the extremity of synthetic oligonucleotides allows the self-assembly of large chemical libraries in which every chemical moiety is associated to a unique DNA sequence, serving as an 'identification bar code'. In this article, we describe the principles, the potential, and the challenges of this novel technology, which promises to facilitate the isolation of high-affinity binders to protein targets of biological and pharmaceutical interest.