Open AccessSelective Synthesis of Fluorinated Compounds: Process Development and Preparation of Fluorinated Compounds from Gram up to Kilogram Scale
Author(s) -
Heinz Steiner,
Hans Meier
Publication year - 2004
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942904777678145
Subject(s) - catalysis , enantioselective synthesis , chemistry , organic chemistry , combinatorial chemistry
The most versatile fluorination reactions for the preparation of up to kg amounts of fluorinated compounds are presented, i.e. the deoxofluorination of alcohols, oxo compounds and carboxylic acids using SF4, and the conversion of anilines to fluoro aromatics. Furthermore the enantioselective catalytic fluorination of ? -ketoesters is highlighted. The option of outsourcing preparative fluorination is discussed.