Open AccessSynthesis and Biological Properties of Novel Fluoroprostaglandin Derivatives: Highly Selective and Potent Agonists for Prostaglandin Receptors
Author(s) -
Yasushi Matsumuraa,
Takashi Nakanob,
Nobuaki Moria,
Yoshitomi Morizawab
Publication year - 2004
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942904777678073
Subject(s) - receptor , chemistry , prostaglandin e2 receptor , pharmacology , prostaglandin , agonist , combinatorial chemistry , biochemistry , biology
Synthesis of novel 7,7-difluoroprostacyclin and 15-deoxy-15,15-difluoro-PGF2? derivatives will be presented. These compounds show high affinity to prostaglandin receptors and potent biological activities.