Open Access2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists
Author(s) -
Bernd Buettelmann,
Alexander Alanine,
Anne Bourson,
R. Gill,
MariePaule Heitz,
Vincent Mutel,
Emmanuel Pinard,
Gerhard Trube,
R. Wyler
Publication year - 2004
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942904777677579
Subject(s) - nmda receptor , chemistry , in vivo , receptor , stereochemistry , pharmacology , in vitro , combinatorial chemistry , biochemistry , biology , genetics
A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. ?1 and M1 receptors) and are active in vivo .