Open AccessFrom the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents
Author(s) -
Erwin Goetschi,
Peter Angehrn,
Hans Gmuender,
Paul Hebeisen,
Dirk Kostrewa,
Helmut Link,
Thomas Luebbers,
Raffaello Masciadri,
Peter Reindl,
Fabienne Ricklin,
FrankPeter Theil
Publication year - 2003
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942903777679505
Subject(s) - dna gyrase , chemistry , dna , antibiotics , biochemistry , escherichia coli , gene
Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.