Open AccessIGE ANTIBODIES TO MAJOR COMPONENTS OF HOUSE DUST MITE ALLERGEN DER P1 AND DER P2 IN CHILDREN WITH ALLERGIES
Author(s) -
Р. Н. Хоха,
L.B. Zavodnik,
А. М. Khokha,
N. S. Paramonova,
V. V. Ravskaya
Publication year - 2022
Publication title -
žurnal grodnenskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 2413-0109
pISSN - 2221-8785
DOI - 10.25298/2221-8785-2022-20-1-43-49
Subject(s) - allergy , house dust mite , allergen , medicine , immunoglobulin e , mite , immunology , peripheral blood , pyroglyphidae , antibody , biology , ecology
Background. House dust mite allergy is widespread throughout the world. Analysis of the immune response to D. pteronyssinus contributes to understanding the patterns of IgE-mediated response in patients with house dust mite allergy living in different geographic regions. Objective. To establish serum sIgE levels to the major components of the house dust mite allergen Der p1 and Der p2 in children with allergies. Material and methods. We examined 61 children aged 4 to 17 years with symptoms of allergy associated with house dust mite in the period from September 2020 to July 2021. The level of sIgE to rDer p1 and rDer p2 was determined by the ImmunoCAP method. Results. In the study group boys dominated (χ2=11.84, p=0.0006). In the age structure school-age children dominated (χ2=19.74, p 0.05). In children aged 6-12 years, the level of sIgE to Der p1 was higher in girls than in boys (p=0.045). A direct correlation was established between the level of sIgE to Der p1 and Der p2 in all children (r=0.56, p 0.05), but exceeded that in children with the results of skin prick tests «+» (p<0.05). Conclusion. The determination of sIgE levels to the allergenic components of the house dust mite Der p1 and Der p2 is a method for the accurate molecular diagnosis of the house dust mite allergy, allowing for better management of allergic diseases in children.