Open AccessEFFECTS OF NEW PIPERIDINE DERIVATIVES WITH SUBSTITUTIONS IN THE 1ST AND 4TH POSITIONS IN NALOXONE SENSITIVE ANALGESY
Author(s) -
A. A. Vasilyuk,
V. I. Kozlovsky,
Г. С. Ахметова,
V. К. Yu
Publication year - 2021
Publication title -
žurnal grodnenskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 2413-0109
pISSN - 2221-8785
DOI - 10.25298/2221-8785-2021-19-5-501-505
Subject(s) - piperidine , (+) naloxone , analgesic , opioid , pharmacology , antagonist , opioid receptor , mechanism of action , opioid antagonist , stimulation , irritation , chemistry , receptor , medicine , anesthesia , stereochemistry , biochemistry , immunology , in vitro
Background. Despite the wide arsenal of painkillers, pain relief is an urgent interdisciplinary problem that requires a search for new solutions. Purpose of the study. To establish the role of opioid receptors in the mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23. Material and methods. The studies were carried out on 96 white mice of both sexes weighing 30-40 g. The analgesic effect of the compounds was tested on models of thermal and chemical irritation with preliminary administration of the opioid receptor antagonist naloxone. Results. The pain reactions of mice with models of thermal and chemical stimulation in the AGV-22 / AGV-23 + naloxone and AGV-22 / AGV-23 groups were comparable. Conclusions. The mechanism of the analgesic action of the piperidine derivatives AGV-22 and AGV-23 is not associated with the activation of opioid receptors.