Open AccessSTATIN-INDUCED MECHANISMS OF CARBOHYDRATE METABOLISM DISORDERS
Author(s) -
Л. В. Никонова,
S. V. Tishkovskiy
Publication year - 2021
Publication title -
žurnal grodnenskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 2413-0109
pISSN - 2221-8785
DOI - 10.25298/2221-8785-2021-19-2-147-152
Subject(s) - medicine , statin , tolerability , diabetes mellitus , insulin resistance , myocardial infarction , insulin , type 2 diabetes mellitus , observational study , first line , stroke (engine) , carbohydrate metabolism , type 2 diabetes , cardiology , endocrinology , pharmacology , adverse effect , mechanical engineering , engineering
Statins are first-line medications that are used to prevent cardiovascular diseases. They reduce the risk of myocardial infarction, stroke, and cardiovascular death by an average of 25-30%. Despite the safety and relative tolerability of statins, observational and clinical studies as well as meta-analyses have shown that statins may increase the risk of developing type 2 diabetes mellitus. Statins have been proven to increase insulin resistance and reduce insulin secretion by pancreatic β-cells