Open AccessANALYSIS OF ANTIBIOTIC RESISTANCE OF K. PNEUMONIAE STRAINS ISOLATED IN A MULTIDISCIPLINARY HOSPITAL
Author(s) -
Е. Г. Антонова,
I. V. Zhyltsov
Publication year - 2021
Publication title -
žurnal grodnenskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 2413-0109
pISSN - 2221-8785
DOI - 10.25298/2221-8785-2021-19-1-31-35
Subject(s) - colistin , tigecycline , amikacin , microbiology and biotechnology , antibiotics , klebsiella pneumoniae , antibiotic resistance , polymyxin , medicine , biology , biochemistry , escherichia coli , gene
Background. The prevalence of infections caused by multiple resistant K. pneumoniae strains is an actual problem. Purpose. To investigate antibacterial resistance of hospital strains of K. pneumoniae – causative agents of purulent septic infections, to determine the resistance level of carbapenem-resistant strains of K. pneumoniae to polymyxins, to analyze their main profiles of antibiotic sensitivity. Material and methods. Antibiotic susceptibility of 146 clinical isolates of K. pneumoniae was determined using the disk diffusion method. The method of sequential microdilutions in broth with determination of MIC was used for isolates resistant to carbapenems. Results. For the majority of clinical isolates of K. pneumoniae (85.2%), only 3 antibiotics (colistin, tigecycline and amikacin) showed acceptable activity in vitro. For one strain resistance to all tested antimicrobial drugs was revealed. Conclusion. The data on extremely high resistance of K. pneumoniae to carbapenems, fluoroquinolones and aminoglycosides were confirmed. A high level of colistin resistance was also identified.