Open AccessMITOCHONDRIAL ATP SYNTHASE
Author(s) -
E.V. Uzlova,
С. М. Зиматкин
Publication year - 2020
Publication title -
žurnal grodnenskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 2413-0109
pISSN - 2221-8785
DOI - 10.25298/2221-8785-2020-18-6-648-654
Subject(s) - atp synthase , mitochondrion , atp synthase gamma subunit , chemiosmosis , enzyme , atp–adp translocase , biochemistry , v atpase , inner mitochondrial membrane , f atpase , chemistry , biology , microbiology and biotechnology , atpase , atp hydrolysis , gene , thylakoid , chloroplast
In the following review we collected and analyzed the currently available data on the structure and organization, localization, working mechanisms and functions of a universal and unique in its characteristics enzyme of ATP synthesis – ATP synthase. In addition to synthase and hydrolase activity, associated into dimers mitochondrial ATP synthase is responsible for “bending” the inner membrane of mitochondria. A large number of diseases, including neurodegenerative and mitochondrial ones, are associated with ATP synthase disorders, and among other things they are accompanied by structural changes of mitochondrial cristae.