Open AccessRifampicin- and allopurinol-induced Stevens-Johnson syndrome: A case series
Author(s) -
Bhavana Srivastava,
Reena Bhardwaj,
Renu Khanchandani,
Zafar Masood Ansari,
Gunjita Belwal
Publication year - 2021
Publication title -
indian journal of physiology and pharmacology (online)/indian journal of physiology and pharmacology
Language(s) - English
Resource type - Journals
eISSN - 2582-2799
pISSN - 0019-5499
DOI - 10.25259/ijpp_386_2020
Subject(s) - allopurinol , medicine , dermatology , erythema multiforme , rifampicin , toxic epidermal necrolysis , mucocutaneous zone , rash , skin biopsy , hypersensitivity reaction , tuberculosis , disease , pathology , biopsy
Stevens-Johnson syndrome (SJS) is a rare, serious disorder and may be life threatening affecting mainly mucocutaneous tissues. It is a type of generalised, multisystemic hypersensitivity reaction directly linked to the drug intake. It is one of the few serious adverse effects of drugs involving skin and mucous membranes which are characterised by rash, bullae and blisters spread on skin, mucous membranes, swelling with erosive lesions on lips and face and hyperpigmentation. Normally, SJS is a self-resolving condition but it has potential to be converted into life-threatening disease. Here, we describe and present a case series of SJS inflicted by rifampicin and allopurinol. First one is a 28-year-old-female and second case is a 50-year-old male, both received rifampicin for pulmonary tuberculosis. Third patient is a 22-year-old young male taken allopurinol for hyperuricemia. All these patients noticed a severe skin reaction which is a part of erythema multiforme spectrum. Causality assessment was done in these patients with the help of Naranjo’s algorithm and diagnosed as cases of SJS.