Open AccessSynergistic Occurrence of EGFR, ALK, and KRAS Gene Mutations in a Patient with Non-small Cell Lung Cancer (Adenocarcinoma)
Author(s) -
Dinesh Chandra Doval,
Rupal Tripathi,
Kumardeep Dutta Choudhury,
Ajay Sharma,
Ullas Batra,
Anurag Mehta,
Partha S Choudhury
Publication year - 2019
Publication title -
indian journal of medical sciences/indian journal of medical sciences (print)
Language(s) - English
Resource type - Journals
eISSN - 1998-3654
pISSN - 0019-5359
DOI - 10.25259/ijms_3_2019
Subject(s) - medicine , kras , adenocarcinoma , lung cancer , malignancy , oncology , disease , chemotherapy , adenocarcinoma of the lung , cancer , lung , stage (stratigraphy) , cancer research , colorectal cancer , biology , paleontology
Lung cancer is a commonly diagnosed malignancy. Adenocarcinoma, a subgroup of non-small cell lung cancer, is the commonest form and presents in an advanced stage of the disease, leaving a limited treatment option. Response to the standard chemotherapy regimens is overall poor. We present a case of synergistic occurrence of triple gene mutations in a patient with well-diff erentiated adenocarcinoma lung treated at a tertiary cancer care center in North India.