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Phenytoin-induced aplastic anemia in generalized tonic clonic seizures patient: A case report
Author(s) -
P. Hima Bindu,
Shradha Vidyadhar Naik,
Paruvelli Krishnaveni,
Gundapaneni Paparayudu,
Varun Lal
Publication year - 2020
Publication title -
indian journal of medical sciences/indian journal of medical sciences (print)
Language(s) - English
Resource type - Journals
eISSN - 1998-3654
pISSN - 0019-5359
DOI - 10.25259/ijms_23_2019
Subject(s) - medicine , pancytopenia , phenytoin , aplastic anemia , anemia , adverse effect , anticonvulsant , pediatrics , epilepsy , anesthesia , bone marrow , psychiatry
Aplastic anemia is a hematopoietic stem cell disorder characterized by pancytopenia of the peripheral blood and hypocellular bone marrow. Phenytoin is the most commonly and most widely used anticonvulsant, which is used for the prevention and treatment of generalized seizures, partial seizures, and status epileptics. The main aim of the study is to enlighten the drug-related problem and address such problems to prevent the occurrence of adverse event and optimizing drug therapy. Here, we present a case of a 35-year-old female patient who was admitted with complaints of fever, breathlessness, and lower limb swelling. She is a known case of hypertension and generalized tonic clonic seizures for which was taking tablet amlodipine and tablet phenytoin from 5 and 2 years, respectively, after which the patient developed aplastic anemia.

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