Chronic myelomonocytic leukemia-1 in a post-renal transplant patient | Zendy

Priyanka Srivastava | Zendy; Umapati Hegde | Zendy; Shailesh Soni | Zendy; T Singh | Zendy

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Chronic myelomonocytic leukemia-1 in a post-renal transplant patient

Author(s) -

Priyanka Srivastava,

Umapati Hegde,

Shailesh Soni,

T Singh

Publication year - 2020

Publication title -

international journal of molecular and immuno oncology

Language(s) - English

Resource type - Journals

eISSN - 2836-3779

pISSN - 2456-3994

DOI - 10.25259/ijmio_24_2019

Subject(s) - azathioprine , medicine , chronic myelomonocytic leukemia , myeloid leukemia , transplantation , monosomy , leukemia , acute myelomonocytic leukemia , gastroenterology , myelodysplastic syndromes , immunology , disease , chromosome , bone marrow , karyotype , biology , biochemistry , gene

Azathioprine is a commonly used immunosuppressive agent in renal transplantation. Thiopurine therapy is associated with an increased risk of solid organ malignancies after renal transplantation. There are few reported cases of azathioprine therapy-related myelodysplastic syndrome/acute myeloid leukemia. We describe a case of post-renal transplant patients developing chronic myelomonocytic leukemia-1 associated with monosomy of chromosome 7, possibly related to prolonged exposure of azathioprine.

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