Open AccessChronic myelomonocytic leukemia-1 in a post-renal transplant patient
Author(s) -
Priyanka Srivastava,
Umapati Hegde,
Shailesh Soni,
Tejinder Singh
Publication year - 2020
Publication title -
international journal of molecular and immuno oncology
Language(s) - English
Resource type - Journals
eISSN - 2836-3779
pISSN - 2456-3994
DOI - 10.25259/ijmio_24_2019
Subject(s) - azathioprine , medicine , chronic myelomonocytic leukemia , myeloid leukemia , transplantation , monosomy , leukemia , acute myelomonocytic leukemia , gastroenterology , myelodysplastic syndromes , immunology , disease , chromosome , bone marrow , karyotype , biology , biochemistry , gene
Azathioprine is a commonly used immunosuppressive agent in renal transplantation. Thiopurine therapy is associated with an increased risk of solid organ malignancies after renal transplantation. There are few reported cases of azathioprine therapy-related myelodysplastic syndrome/acute myeloid leukemia. We describe a case of post-renal transplant patients developing chronic myelomonocytic leukemia-1 associated with monosomy of chromosome 7, possibly related to prolonged exposure of azathioprine.