Open AccessPhiladelphia-positive precursor B-cell acute lymphoblastic leukemia in elderly alcoholic patient – A case report
Author(s) -
Vijay Suri,
Gunjan Bala,
Ramit Gupta,
Shikha Narang,
Anshul Gupta,
Nidhi Bansal
Publication year - 2019
Language(s) - English
DOI - 10.25259/aujmsr_2_2019
Subject(s) - medicine , philadelphia chromosome , lymphoblast , myeloid leukemia , abnormality , lymphoblastic leukemia , pediatrics , weakness , leukemia , chromosomal translocation , psychiatry , surgery , gene , genetics , biology , cell culture
Philadelphia chromosome is well-known chromosomal abnormality in chronic myeloid leukemia (CML). However, B-acute lymphoblastic leukemia (B-ALL) with Philadelphia-positive (Ph′) is a neoplasm of lymphoblast committed to the B-cell lineage. The clinical presentation of B-ALL Ph′+ is similar to B-ALL but is more common in adults than in children. Our 50-year-old male patient presented to psychiatry OPD for deaddiction of alcohol. The patient also complained of generalized weakness and pain in legs which may have been due to chronic alcoholism. He was further investigated and diagnosed as B-precursor ALL with positive BCR-ABL fusion gene. Here, we like to emphasize that overlapping symptoms may lead to delay in diagnosis, so clinician should always investigate the patient thoroughly so that the patient is diagnosed on time and treatment can be started as early as possible and fatal outcomes can be avoided.