Open AccessAntifungal Activity of Geraniol on Candida albicans Isolates of Pediatric Clinical Importance
Author(s) -
Ana Raquel Carmo de Lima,
Jossana Pereira de Sousa,
Lílian Sousa Pinheiro,
Abrahão Alves de Oliveira Filho,
Edeltrudes O. Lima
Publication year - 2017
Publication title -
international journal of pharmacognosy and phytochemical research
Language(s) - English
Resource type - Journals
ISSN - 0975-4873
DOI - 10.25258/phyto.v9i4.8131
Subject(s) - geraniol , ergosterol , candida albicans , minimum inhibitory concentration , antifungal , microbiology and biotechnology , phytochemical , broth microdilution , biology , monoterpene , sorbitol , ocimum , chemistry , traditional medicine , chromatography , antimicrobial , food science , biochemistry , botany , medicine , essential oil
Geraniol is a plant-derived monoterpene alcohol that has antifungal effect. The aim of this study was to evaluate thegeraniol for antifungal activity against Candida albicans isolates of pediatric clinical importance. The minimum inhibitoryconcentration (MIC) and the minimum fungicidal concentration (MFC) were determined by the broth microdilutiontechniques. We also investigated possible geraniol action on cell walls (0.8M sorbitol) and cell membranes (Geraniol toergosterol binding). For 90% of isolates, the MIC and MFC of the phytochemical was 64