Open AccessAntileishmanial Effect of Berberine and extracts of Berberis vulgaris on the Growth of Leishmanial Species
Author(s) -
Zina K. Najim,
Husain F. Hassan
Publication year - 2020
Publication title -
international journal of pharmaceutical quality assurance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.114
H-Index - 7
ISSN - 0975-9506
DOI - 10.25258/ijpqa.11.2.8
Subject(s) - berberine , berberis , traditional medicine , berberidaceae , berberine hydrochloride , chemistry , biology , leishmania donovani , high performance liquid chromatography , botany , chromatography , biochemistry , leishmaniasis , visceral leishmaniasis , medicine , immunology
The present investigation was revealed that the Berberine (0.01, 0.1, 1 mg/cm3), aqueous extracts and alcoholic extract (1,10,100 mg/cm3) of Berberis vulgaris roots were inhibitory on the growth of Leishmania tropica, L. donovani, and L. infantum promastigotes. High-pressure liquid chromatography (HPLC) analysis of the plant extracts proved to contain Berberine as an active compound. Berberine and B. vulgaris root extracts were caused a significant decrease in total nucleic acid contents of three leishmanial species, thus, considering to be an excellent agents for antileishmanial chemotherapy.