Antileishmanial Effect of Berberine and extracts of Berberis vulgaris on the Growth of Leishmanial Species | Zendy

Zina K. Najim | Zendy; Husain F. Hassan | Zendy

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Antileishmanial Effect of Berberine and extracts of Berberis vulgaris on the Growth of Leishmanial Species

Author(s) -

Zina K. Najim,

Husain F. Hassan

Publication year - 2020

Publication title -

international journal of pharmaceutical quality assurance

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.114

H-Index - 7

ISSN - 0975-9506

DOI - 10.25258/ijpqa.11.2.8

Subject(s) - berberine , berberis , traditional medicine , berberidaceae , berberine hydrochloride , chemistry , biology , leishmania donovani , high performance liquid chromatography , botany , chromatography , biochemistry , leishmaniasis , visceral leishmaniasis , medicine , immunology

The present investigation was revealed that the Berberine (0.01, 0.1, 1 mg/cm3), aqueous extracts and alcoholic extract (1,10,100 mg/cm3) of Berberis vulgaris roots were inhibitory on the growth of Leishmania tropica, L. donovani, and L. infantum promastigotes. High-pressure liquid chromatography (HPLC) analysis of the plant extracts proved to contain Berberine as an active compound. Berberine and B. vulgaris root extracts were caused a significant decrease in total nucleic acid contents of three leishmanial species, thus, considering to be an excellent agents for antileishmanial chemotherapy.

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