Open AccessDevelopment of a Novel Method for Quantitative Determination of Indomethacin
Author(s) -
Ali Rasool Mahmood Albakaa,
Nehad K. Abed,
Dina Saleem M. Ameen,
Zainab A. Jabbar,
Amany S. Younis
Publication year - 2020
Publication title -
international journal of drug delivery technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.133
H-Index - 9
ISSN - 0975-4415
DOI - 10.25258/ijddt.10.1.8
Subject(s) - absorbance , ultraviolet visible spectroscopy , calibration curve , wavelength , analytical chemistry (journal) , correlation coefficient , spectroscopy , ultraviolet , linear relationship , linear regression , chemistry , materials science , molar ratio , chromatography , mathematics , physics , detection limit , organic chemistry , optoelectronics , statistics , quantum mechanics , catalysis
A new green analytical chemistry method using a Ultraviolet–visible (UV-Vis) Spectroscopy is proposed to measure Indomethacin (as cuprous complex); Designate, sophisticated, and proved for determination pure mode of indomethacin, and at dosage forms respective.The present study was prepared quantitatively of the Indomethacin complex, and the molar ratio between the cuprous and indomethacin (1:1) is measured by UV-Vis spectroscopy, the maximum absorbance peak of cuprous complex was measured at (319 nm) in wavelength range (190‐900 nm), at range of the concentration (10–60μg.mL-1) the linear calibration curve was painted and show regression equation (Y = 0.0036X – 0.0054) and correlation Coefficient (R2 = 0.9999).This study was validated and applied to the estimation of indomethacin in tablets from one company in Iraqi markets, when the wavelength and the analysis conditions were determined, no interference was found. It was concluded that the advanced method was accurate, sensitive, precise, and repeatable.