Open AccessUtilization of Poloxamer as Well as Combinations with Other Polymers as Base in Ophthalmic in Situ Gel Dosage Form
Author(s) -
Insan Sunan Kurniawansyah,
Taofik Rusdiana,
Iyan Sopyan,
Anas Subarnas,
Habibah A. Wahab
Publication year - 2020
Publication title -
international journal of drug delivery technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.133
H-Index - 9
ISSN - 0975-4415
DOI - 10.25258/ijddt.10.1.28
Subject(s) - poloxamer , in situ , eye irritation , chromatography , irritation , dosage form , polymer , poloxamer 407 , in vivo , chemistry , self healing hydrogels , drug delivery , materials science , biomedical engineering , polymer chemistry , copolymer , medicine , organic chemistry , microbiology and biotechnology , immunology , biology
The aim of this review was to find out which formulation were good for making in-situ gels using a combination of poloxamer and other bases. Formulation was characterized for appearance and homogeneity, pH and gelation studies, viscosity measurements, in vitro drug release, drug content, and stability studies. In vivo rabbit, eye irritation tests were conducted to evaluate the irritation of the in-situ gel delivery system; in addition, osmolality testing, sterility test, and isotonicity evaluation were also carried out. The results have shown that in-situ gel solution can increase residence time and also maintain the mechanism of drug release.