Open AccessSynthesis and Characterization of Orotic Acid Loaded Chitosan Inclusion Complex
Author(s) -
Abdelkader Hassani,
Abul Kalam Azad,
Hamid Hammad Enezei,
Siti Aslina Hussain,
Abul Bashar Mohammed Helaluddin
Publication year - 2020
Publication title -
international journal of drug delivery technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.133
H-Index - 9
ISSN - 0975-4415
DOI - 10.25258/ijddt.10.1.1
Subject(s) - differential scanning calorimetry , fourier transform infrared spectroscopy , zeta potential , chitosan , nuclear chemistry , orotic acid , drug delivery , materials science , characterization (materials science) , chemistry , transmission electron microscopy , analytical chemistry (journal) , chemical engineering , nanotechnology , chromatography , nanoparticle , organic chemistry , biochemistry , physics , engineering , thermodynamics
The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/CS was carried out using fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), zeta sizer, and transmission electron microscopy (TEM). Furthermore, the size of OA/CS ranged between 58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop a carrier for drug delivery systems further.