Synthesis and Characterization of Orotic Acid Loaded Chitosan Inclusion Complex | Zendy

Abm Helal Uddin | Zendy; Abdelkader Hassani | Zendy; Абул Калам Азад | Zendy; Hamid Hammad Enezei | Zendy; Siti Aslina Hussain | Zendy

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Synthesis and Characterization of Orotic Acid Loaded Chitosan Inclusion Complex

Author(s) -

Abm Helal Uddin,

Abdelkader Hassani,

Абул Калам Азад,

Hamid Hammad Enezei,

Siti Aslina Hussain

Publication year - 2020

Publication title -

international journal of drug delivery technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.133

H-Index - 9

ISSN - 0975-4415

DOI - 10.25258/ijddt.10.1.1

Subject(s) - differential scanning calorimetry , fourier transform infrared spectroscopy , zeta potential , chitosan , nuclear chemistry , orotic acid , drug delivery , materials science , characterization (materials science) , chemistry , transmission electron microscopy , analytical chemistry (journal) , chemical engineering , nanotechnology , chromatography , nanoparticle , organic chemistry , biochemistry , physics , engineering , thermodynamics

The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/CS was carried out using fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), zeta sizer, and transmission electron microscopy (TEM). Furthermore, the size of OA/CS ranged between 58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop a carrier for drug delivery systems further.

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