Open AccessPlantas medicinales como alternativa terapéutica para el trastorno Depresivo Mayor (DMD)
Author(s) -
Thallysson Jose Dourado de Sousa,
Pedro Henrique Almeida de Faria,
Kassyo Lenno Sousa Dantas,
Monick Nielly Miranda Pinto,
Gabriella de Assis Malerba,
Milena Sousa Freitas,
Sheyrlani Tatiany da Silva,
Paulo César Morales Mayer,
Domingos Magno Santos Pereira,
Cristiane Santos Silva e Silva Figueiredo
Publication year - 2021
Publication title -
revista eletrônica acervo saúde
Language(s) - English
Resource type - Journals
ISSN - 2178-2091
DOI - 10.25248/reas.e5646.2021
Subject(s) - antidepressant , serotonergic , reuptake , dopaminergic , dopamine , medicine , reuptake inhibitor , pharmacology , serotonin , serotonin syndrome , psychiatry , psychology , neuroscience , anxiety , receptor
Objective: To review the antidepressant activity and mechanisms of action of plants that have antidepressant action. Literature Review: The use of plants for medicinal purposes has been used as an adjunct to the treatment of depression due to easy access by the population, few side effects and lower cost. Based on the studies, the plants St. John's wort, ground turmeric, anona and lavender have antidepressant potential for acting in different ways in depression, either by inhibiting the reuptake of serotonin or by modulation in the dopaminergic and serotonergic pathways. Final Considerations: From the studies of the mechanisms of action it was found that the plants studied can modulate the brain signaling pathways responsible for the patient's mood, with the reuptake of serotonin (inhibition of the serotonin transporter protein) the main mechanism of action shared between them. In addition, some of these plants can modulate not only the concentrations of serotonin in the synaptic cleft, but also dopamine. It is worth mentioning that, although these actions have been scientifically proven, much research is still needed to ensure the safe use of these agents as herbal medicines in the alternative or adjunctive treatment of depressive disorders.