Open AccessReproductive Toxicity of Eugenol in Wistar Rats
Author(s) -
Jamilka Leopoldina da Silva,
Anne Catharine Tavares de Azevedo Marinho,
Lady Dayane Kalline Travassos dos Prazeres,
Teresinha Gonçalves da Silva,
Kleison da Costa Merlo,
Henrique Bandeira Alves Costa,
Almir Gonçalves Wanderley
Publication year - 2019
Publication title -
revista eletrônica acervo saúde
Language(s) - English
Resource type - Journals
ISSN - 2178-2091
DOI - 10.25248/reas.e1864.2019
Subject(s) - organogenesis , eugenol , fetus , toxicity , developmental toxicity , pregnancy , medicine , oral administration , physiology , biology , andrology , chemistry , biochemistry , genetics , organic chemistry , gene
Objective: To analyze the effects of eugenol oral administration during pre-implantation and organogenesis periods in pregnant Wistar rats. Methodology: The animals were divided into eight experimental groups (4 groups for each period) subdivided into control groups and daily treated with eugenol at doses of 37.5, 187.5 and 375 mg/kg/day (n= 9) during pre-implantation or organogenesis phases. Results: At all tested doses of eugenol, the groups treated during the pre-implantation presented alterations in the maternal organs, increased pre-and post-implantation loss and stillbirth records. The groups treated during organogenesis also presented alterations in the maternal organs and reduction of the placental indexes, added to the skeletal alterations, in all treatment doses. There were no significant fetal visceral changes. Conclusions: Oral administration of eugenol reduced maternal reproductive capacity in the pre-implantation phase and promoted toxic effects and fetal malformations in organogenesis.