Open AccessStudies on effectiveness and safety of system retinoids use in therapy ofadolescent acne
Author(s) -
Н. Н. Мурашкин,
А. М. Иванов,
Denis V. Zaslavsky,
T A Kamilova
Publication year - 2010
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv983
Subject(s) - isotretinoin , acne , retinoid , medicine , dermatology , biology , genetics , retinoic acid , gene
The article describes up-to-date data on mechanics of epigenetic effects of system retinoid - isotretinoin (Roaccutane). It isnoted, that modern acne therapy is able not only to pathogenetically influence consequences of the process, but effect geneticalcauses of desease, leading to persistant changes and normalization of regulatory segments DNA structure under influence ofisotretinoin. Also this article lists data on the use of isotretinoin (Roaccutane) for acne treatment of 237 adolescents. Studies wereperformed on frequency of occurrence, degree of manifestation of secondary effects and methods of levereging this effects inpractical use. Authors state that correctly prescribed treatments are safe and do not cause serious secondary effects with in caseof long treatmetns.