Open AccessFunctions of Toll-like receptors as an inborn immunity component and their participation in the pathogenesis of dermatoses of different etiologies
Author(s) -
О Р Катунина
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv978
Subject(s) - pathogenesis , immune system , etiology , receptor , immunology , toll , immunity , acquired immune system , toll like receptor , innate immune system , biology , pattern recognition receptor , medicine , pathology , genetics
In addition to serving as a mechanical barrier protecting our organism from the damaging effect of different factors, our skin also takes part in immune reactions developing in case of microbial intervention. Toll-like receptors (TLR) mediating recognition of molecular structures of pathogens are expressed in skin cells of different types initiating the development of adaptive immune reactions when associated with different ligands. The review presents data on the structure and functions of TLR, their localization in skin compartments and their role in the pathogenesis of skin diseases being of infectious etiology and non-infectious origin.