Open AccessRole of recognizing receptors in the initiation of immune inflammation in theskin of psoriasis patients
Author(s) -
О Р Катунина,
А. В. Резайкина,
O I Kolykhalova
Publication year - 2010
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv964
Subject(s) - tlr2 , psoriasis , receptor , tlr4 , toll , immune system , inflammation , tlr9 , immunology , toll like receptor , pattern recognition receptor , medicine , innate immune system , biology , gene , gene expression , biochemistry , dna methylation
The article presents data on the pathogenetic role of Toll-like receptors in the development of immunopathological reactions in theskin. The authors examined the distribution and content of Toll-like receptors TLR2, TLR4 and TLR9 in the affected skin of psoriasispatients. They revealed a statistically significant increase in expression of Toll-like receptors TLR2 and TLR4, which can play animportant role for the formation of the inflammatory process involving cells of the adaptive immune system.