Open AccessOn quality of serological diagnostics of syphilis in dermatovenerologicalinstitutions of the russian federation
Author(s) -
С В Ротанов,
Н В Фриго,
А. А. Кубанова,
Ye L Vasiliyeva
Publication year - 2010
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv933
Subject(s) - serology , syphilis , venereology , medicine , immunofluorescence , syphilis serodiagnosis , antibody , immunology , pathology , human immunodeficiency virus (hiv)
The article presents the results of a cycle of external quality control of serological tests for diagnostics of the syphilitic infectionconducted by FGU GNTsD Rosmedtekhnologiy (State Research Center for Dermatology and Venereology of the FederalAgency for High-Technology Medical Aid) in 2009 in 125 serology laboratories of dermatovenerological institutions in differentsubjects of the Russian Federation. The authors evaluated the quality of serological tests (microprecipitation test, RPR, passivehemagglutination test, immunofluorescence test and immune-enzyme assay) of four reference serum samples based on formaland essential characteristics. The percentage of non-satisfactory results of studies for a set of reference serum samples in nontreponemaltests (microprecipitation test and RPR) was 10.9%; in treponemal tests: in immune-enzyme assay - 1.4%, in passivehemagglutination test - 1.2%, in immunofluorescence test - 0.9%. The most significant differences in the results were revealedin studies of reference serum samples with the low content of antibodies (weakly positive) as well as those that contained noantibodies to the syphilis causative agent.