Open AccessClinical, molecular and genetic studies of efficacy and safety of using UV irradiation for psoriasis patients
Author(s) -
М. Б. Жилова,
А. А. Кубанов,
I N Lesnaya,
Н В Фриго,
I A Volkov,
L F ZNAMENSKAYA,
В. А. Волнухин
Publication year - 2010
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv902
Subject(s) - psoriasis , phototoxicity , genotype , dermatology , medicine , genetic enhancement , gene , pharmacology , genetics , biology , in vitro
The authors give the results of clinical, molecular and genetic studies of efficacy and safety of treatment of 87 patients sufferingfrom extensive psoriasis with the use of UV irradiation of different spectral ranges. They showed that the administration of a courseof treatment with the use of the PUVA therapy or narrowband medium-wave UV therapy with the wavelength of 311 nm does notresult in the development of any clinically significant genetic mutations associated with the DNA excision repair system. Theyrevealed that the GC genotype of the XPC gene in the 32828 site and CC genotype of the XPF gene in the 27945 site maybe predictors of a pronounced therapeutic effect in treatment of patients with the use of phototherapy methods. The authorsobtained data confirming a possible protective role of T>C polymorphism in the 27945 site of the XPF gene in the development ofphototoxic reactions when psoriasis patients undergo an UV therapy.