Open AccessPossibility to use Ademetionine for the treatment of psoriaticpatients with a pathology of the hepatobiliary system
Author(s) -
С. Л. Матусевич,
И. В. Медведева,
С. Л. Матусевич,
И. В. Медведева
Publication year - 2010
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv819
Subject(s) - concomitant , gastroenterology , medicine , urine , blood plasma , pathology , endocrinology , chemistry
The endogenous intoxication syndrome manifested in the form of excessive accumulation of low and mean molar mass substancesin plasma and urine as well as increased blood plasma concentrations of malonic dialdehyde against the backgroundof reduced alpha-tocopherol was revealed in psoriatic patients with the concomitant hepatobiliary system pathology. Applicationof Ademetionine in the dose of 800 mg per day for 15 days as a part of the complex therapy for such patients as opposed to thepatients receiving standard therapy resulted in reliable reduction in the severity of clinical manifestations of the disease and PASIvalue as well as decrease in the concentration of low and mean molecular mass substances in plasma and erythrocytes, reductionin the blood plasma malonic dialdehyde concentration and increase in alpha-tocopherol.