Open AccessImmune predictors of complications of the urogenital chlamydial infection leading to infertility
Author(s) -
K I PLAHOVA,
Н В Фриго,
M R RAHMATULINA,
С В Ротанов,
R F HAYRULLIN
Publication year - 2012
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv700
Subject(s) - anamnesis , infertility , genitourinary system , immune system , medicine , cytokine , tubal factor infertility , immunology , gynecology , pregnancy , biology , genetics
Goal: determination of immune predictors of the development of complications of the urogenital chlamydial infection (UGCI) in women and further disorder of the reproductive function (infertility) due to the past infection. Маterials and methods. 80 women have been examined: 40 patients with uGCI (20 — with UGCI of lower sections of the urogenital tract and 20 — with pelvic UGCI), 20 patients with secondary (tubal) infertility with the previous UGCI in the anamnesis and 20 clinically healthy women. The qualitative and quantitative study of the spectrum of cytokines (IL-2, -4, -6, -8, -10, INF-γ, TNF α and GM-CSF) with the use of the хМАР multiplex technology in blood and the cervical secretion. Results. The research has determined the spectrum of cytokines with a change in their concentration having an effect on the outcome of UGCI and the development of complications causing disorders of the reproductive function in women: these are TNF-α, IFN-γ, IL-2 inflammatory cytokines аs well as the IL-10 inflammatory cytokine.