Volf’s isotopic response

The term of “isotopic response” was offered by R. Wolf and co-authors in 1995 and means the development of the new dermatosis at the place of already existing initial one, which has already regressed and is not directly referred to the first one. The article describes the essence of the phenomena and most important clinical cases. Such pathogenic mechanisms as viral, immunologic, vascular, neurogenic theory are being discussed, as well as the immunocompromised site concept. The commonality and the difference of the isotopic response and of the isomorphic Kobner’s phenomenon are being analyzed. Two clinical cases are provided.