Open AccessPemphigus pathogenesis: problems and prospects
Author(s) -
А. В. Миченко,
L F ZNAMENSKAYA,
Andrey Lvov,
И А Волков,
Н В Фриго,
В. А. Волнухин
Publication year - 2012
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv682
Subject(s) - pemphigus , pathogenesis , immunology , medicine , genetic predisposition , cites , dermatology , biology , pathology , disease , fishery
Provides the survey of most prospective trends of research of the pathogenesis of the true acantholytic pemphigus. Cites key results of studies of factors of genetic predisposition to the development of this bullous dermatosis. Highlights problems of studies of the role of antiself antibodies and self-antigens in pemphigus pathogenesis. Represents the apoptolyse theory, explaining mechanisms of the loss of link between keratinocytes. Discusses issues of the cellular regulation of autoimmune reactions at acantholytic pemphigus.