Open AccessClinical efficacy, safety and tolerance of 0.1% Tacrolimus ointment in the treatment of atopic dermatitis in the moderate and severe forms
Author(s) -
А. В. Самцов,
А. В. Сухарев,
А. В. Патрушев,
O I BONDAR
Publication year - 2012
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv671
Subject(s) - atopic dermatitis , medicine , tacrolimus , dermatology , scorad , clinical efficacy , quality of life (healthcare) , dermatology life quality index , surgery , psoriasis , transplantation , nursing
Goal: to evaluate the clinical efficacy of 0.1% Protopic ointment in the treatment of atopic dermatitis as a part of a complex therapy. Materials and methods. The study involved a group of 30 patients of both sexes who were diagnosed with atopic dermatitis in the moderate and severe forms at the age of 17—40, who received the 0.1% Tacrolimus ointment (which was applied on the affection foci) as a part of a complex therapy twice a day. The efficacy and safety of this therapy were evaluated based on the SCORAD, Dermatology Life Quality Index (DLQI), indices of personal and situational anxiety, and subjective patient’s feelings. Results. The application of the Protopic ointment resulted in a high total percentage of clinical recovery and significant improvement (86.2%) as well as fast (on Day 7) achievement of a positive effect. Conclusion. The Protopic ointment is characterized by high efficacy and good tolerance when used for the treatment of moderate to severe forms of atopic dermatitis as a part of the complex therapy.