Open AccessSelection of the therapy of herpes viral infection based on the data of the monitoring of the sensitivity of the herpes simplex virus to etiotropic drugs
Author(s) -
Л. М. Алимбарова,
А. А. Лазаренко,
I. F. Barinsky
Publication year - 2012
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv662
Subject(s) - herpes simplex virus , virus , selection (genetic algorithm) , virology , regimen , isolation (microbiology) , virus isolation , herpesviridae , antiviral therapy , medicine , simplexvirus , disease , drug , alphaherpesvirinae , antiviral drug , viral disease , biology , pharmacology , microbiology and biotechnology , computer science , artificial intelligence , chronic hepatitis
The authors present the results of the monitoring of the sensitivity of herpes simplex virus (HSV) strainsin vitro isolated from 110 female patients with various forms of the herpes virus infection to etiotropic drugs (acyclovir (ACV)), valacyclovir) based on the data provided by the phenotypic method. The authors established that 90% of HSV strains were sensitive to ACV irrespective of the isolation conditions, and the share of non-sensitive strains was 10% while the share of strains that were not sensitive to valacyclovir was not higher than 0.9%. These data are of great value for the evaluation of the pathological process activity, forecast for the disease and selection of an individualized treatment regimen for patients providing for the selection of an antiviral drug and its optimum dose in view of the results of virology studies.