Open AccessОn the role of pro-fibrous cytokines in the pathogenesis of localized scleroderma
Author(s) -
В. А. Волнухин,
N L MURADYAN,
О Р Катунина
Publication year - 2012
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv645
Subject(s) - pathogenesis , transforming growth factor , fibrosis , scleroderma (fungus) , platelet derived growth factor receptor , receptor , growth factor , inflammation , cytokine , immunohistochemistry , medicine , immune system , platelet derived growth factor , immunology , pathology , endocrinology , inoculation
The content and skin distribution of the transforming growth factor β1 (TGF-β1), transforming growth factor-β receptor type I receptor (TGF-βRI) and platelet-derived growth factor receptor a (PDGFR-α), which are key fibrosis mediators, were examined in ten patients with localized scleroderma and ten healthy volunteers by using the immunohistochemistry method. A reduced derma concentration of TGF-β1+ cells (р = 0.007) and increased amount of TGF-βRI+ (р = 0.001) and PDGFR-α+ (р < 0.001) cells was discovered in the patients vs. the control group. Te reduced amount of TGF-β1 in the affected loci can be apparently explained by its reduced production by cells taking part in the immune inflammation. Increased expression of TGF-βRI receptors (р = 0.001) and PDGFR-α in the foci of localized scleroderma confirms their important role in the pathogenesis of the disease and activation of the fibrosis process in the skin.