Open AccessImmunohistochemistry detection of kappa-opioid receptors in human skin
Author(s) -
Svetlana Bobko,
Tobias Lotts,
Dieter Metze,
Andrey Lvov,
S Staender
Publication year - 2013
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv585
Subject(s) - κ opioid receptor , immunochemistry , kappa , receptor , immunohistochemistry , medicine , dermis , opioid , basal (medicine) , human skin , pathology , immunology , biology , antibody , linguistics , philosophy , insulin , genetics
The imbalance of p- and kappa-opioid receptors in the skin or central nervous system is currently deemed to be one of the reasons of chronic pruritus. A number of studies demonstrated a positive effect of system agonists of kappa-opioid receptors in the treatment of uremic pruritus, nodular pruritus, paraneoplastic and cholestatic pruritus. This research demonstrates an expression of kappa-opioid receptors in human skin (basal keratinocytes, dendritic cells, epidermal melanocytes and fibroblasts of the upper dermis) detected with the use of different immunochemistry methods.