Open AccessAssessment of the BRAF status in patients with skin melanoma
Author(s) -
С. Н. Гырылова,
Т. Г. Рукша,
С. Н. Зобова,
А. В. Комина,
М. Б. Аксененко,
С. Н. Гырылова,
Т. Г. Рукша,
С. Н. Зобова,
А. В. Комина,
М. Б. Аксененко
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv1081
Subject(s) - melanoma , medicine , histology , pathological , v600e , mutation , dermatology , neoplasm , skin cancer , stage (stratigraphy) , pathology , oncology , cancer research , gene , cancer , biology , genetics , paleontology
Skin melanoma is an aggressive malignant neoplasm. Mutation of the BRAF gene, BRAF V600E, is observed in more than70% of melanoma cases. Assessment of the BRAF status in patients suffering from skin melanoma is an important stagein patient screening for selection of further therapy.To reveal the mutation of BRAF V600E, 27 histology samples taken from patients with skin melanoma residing in theKrasnodar territory were examined by means of defining the Restriction Fragment Length Polymorphism (PFLP assay).Our studies revealed the BRAF V600E mutation in 26 of 27 histology samples of skin melanoma. It was shown that themutation is not associated with any sex-related, age-related, clinical and pathological features of the tumor.