Open AccessWhat is a combination treatment and how it may be used in onychomycosis
Author(s) -
Y. V. Sergeev,
V. Yu. Sergeev,
Y. V. Sergeev,
A. Y. Sergeev
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv1080
Subject(s) - antifungal , medicine , dermatology , combination therapy , nail (fastener) , clinical trial , treatment modality , lacquer , intensive care medicine , surgery , pharmacology , nanotechnology , materials science , metallurgy , coating
Combination treatment of onychomycosis is based on supplementation of systemic antifungal therapy with differenttopical techniques, which now include antifungal nail lacquers. Controversies in establishing potential and efficacy ofcombination treatment in onychomycosis may be overcome by rational administration of any treatment modality aftercareful evaluation of both the disease and the patient. Application of antifungal nail varnishes such as 8% ciclopiroxoffers several benefits in treating onychomycosis. With improved efficacy and safety, onychomycosis combinationtherapy appears to be less expensive and more reliable in terms of reduced rates of relapse and re-infection. Russianand international clinical trials and studies with ciclopirox nail lacquer have revealed the indications and proved the higheffectiveness of certain algorithms of combination treatment.