Open AccessAssociation of polymorphism of IL12B gene and predisposition to psoriasis among the populationof the Northwestern region of Russia
Author(s) -
V. Khayrutdinov,
A F Mikhaylichenko,
A A Piskunova,
А. В. Самцов,
А. М. Иванов,
Evgeny N. Imyanitov,
В. Р. Хайрутдинов,
А. Ф. Михайличенко,
A A Piskunova,
А. В. Самцов,
А. М. Иванов,
YE N IMYANITOV
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv1079
Subject(s) - genotyping , psoriasis , psoriatic arthritis , allele , genetic predisposition , genotype , polymerase chain reaction , gene polymorphism , medicine , genetics , gene , immunology , biology
The IL12B gene encodes protein р40 being a common subunit of interleukin-12 and interleukin-23 playing an importantpart in the pathogenesis of psoriasis. The IL12B gene has polymorphism rs12188300, which can be associated with therisk of psoriasis development. The goal of the study was to assess the distribution of alleles of polymorphism rs12188300in psoriatic patients in the Northwestern region of Russia. Genotyping was carried out using the real-time allele-specificpolymerase chain reaction. An increased occurrence of a rare allele T in psoriatic patients as compared to healthy peoplewas observed (OR = 1.96, р = 0.0007). The occurrence of the rare allele T in patients with psoriatic arthritis was higherthan in the control group (OR = 3.49, р = 0.005). These results suggest that rs12188300 polymorphism of the IL12B geneis a new genetic marker of psoriasis and psoriatic arthritis.