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Sinus histiocytosis (Rosai-Dorfman disease): a clinical observation
Author(s) -
Andrey Lvov,
I N Voloshchuk,
Vladimir Varshavskiy,
Yu.V. Gorbacheva,
Svetlana Bobko,
Andrey Lvov,
I N Voloshchuk,
V A Varshavsky,
Yu.V. Gorbacheva,
Svetlana Bobko
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv1076
Subject(s) - rosai–dorfman disease , histiocyte , sinus histiocytosis with massive lymphadenopathy , histiocytosis , pathology , disease , medicine , differential diagnosis , langerhans cell histiocytosis , emperipolesis , lymph , dermatology
The authors characterized a heterogeneous group of a rare disease - Langerhans and non-Langerhans cell histiocytosis,and analyzed key differential and diagnostic differences between these forms of the disease. A very rare case of non-Langerhans cell histiocytosis (Rosai-Dorfman disease) in a female patient aged 63 with the subsequent spontaneousregression of eruptions was described. Key skin manifestations of the Rosai-Dorfman disease included papular eruptionsof the typical intense pink color with a yellowish and brown tint. Morphologic changes were characterized by proliferationof histiocytes and accumulation of different lipids and pentalamellar markers (S-100 protein, СD 14, СD 68, lysozyme)in their cytoplasm. Though the Rosai-Dorfman disease usually involves lymph nodes, this case was characterized byunaffected nodular structures.

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