Sinus histiocytosis (Rosai-Dorfman disease): a clinical observation

The authors characterized a heterogeneous group of a rare disease - Langerhans and non-Langerhans cell histiocytosis,and analyzed key differential and diagnostic differences between these forms of the disease. A very rare case of non-Langerhans cell histiocytosis (Rosai-Dorfman disease) in a female patient aged 63 with the subsequent spontaneousregression of eruptions was described. Key skin manifestations of the Rosai-Dorfman disease included papular eruptionsof the typical intense pink color with a yellowish and brown tint. Morphologic changes were characterized by proliferationof histiocytes and accumulation of different lipids and pentalamellar markers (S-100 protein, СD 14, СD 68, lysozyme)in their cytoplasm. Though the Rosai-Dorfman disease usually involves lymph nodes, this case was characterized byunaffected nodular structures.