Open AccessChanges in the hormonal status of patients with focal psoriasis vulgaris
Author(s) -
Андрей Глебович Васильев,
D V Zaslavskiy,
Alexander P. Trashkov,
Алефтина Алексеевна Кравцова,
S R Kazikhanova,
V. Khayrutdinov,
М. Г. Хведелидзе,
A G VASILIYEV,
Denis V. Zaslavsky,
Alexander P. Trashkov,
Алефтина Алексеевна Кравцова,
S R Kazikhanova,
В. Р. Хайрутдинов,
М. Г. Хведелидзе
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv1069
Subject(s) - psoriasis , cortisone , medicine , prolactin , immune system , hormone , endocrine system , disease , endocrine disease , physiology , immunology , gastroenterology , pathology , endocrinology , dermatology
Cell differentiation affections substantiate the urgency of the problem related to studying mutual impact of primary orsecondary endocrine pathology and hyperproliferative skin diseases. Psoriasis is one of the most demonstrative pathologiesfor this study for being a prevalent and genetically predetermined disease with a chronic and relapsing course characterizedby increased proliferation of keratinocytes, abnormal differentiation process of epidermis cells, inflammatory and immunechanges in derma, and dyshormonal disorders are among factors triggering the disease. The study involved 61 male patients.The study group (n = 43) comprised patients with circumscribed psoriasis vulgaris at the progression stage while the controlgroup (n = 18) comprised healthy people. Blood concentration of such hormones as prolactin and cortisone was assessedby the immune-enzyme assay method. An increased cortisone concentration in patients suffering from psoriasis vs. controlgroup was revealed. Psoriatic patients tend to have an increased prolactin level.