Open AccessMarkers of efficacy of Infliximab in psoriasis patients
Author(s) -
А. А. Кубанова,
L F ZNAMENSKAYA,
Н В Фриго,
И А Волков,
С В Ротанов,
A V Rezaykina,
А. А. Кубанова,
L F ZNAMENSKAYA,
Н В Фриго,
И А Волков,
С В Ротанов,
А. В. Резайкина
Publication year - 2011
Publication title -
vestnik dermatologii i venerologii
Language(s) - English
Resource type - Journals
eISSN - 2313-6294
pISSN - 0042-4609
DOI - 10.25208/vdv1066
Subject(s) - infliximab , psoriasis , medicine , genotype , gastroenterology , clinical efficacy , locus (genetics) , dermatology , tumor necrosis factor alpha , gene , biology , genetics
The article presents the results of molecular and genetic studies aimed at determination of molecular markers for forecastingthe clinical response of psoriasis patients to treatment with Infliximab. The authors revealed that it is possible to forecasthigh efficacy of treatment with Infliximab in case TT genotype is revealed at the 676 locus of exon 6 of the TNF-RII gene andIL-10 is present in the blood serum prior to the onset of treatment in the amount of more than 2.7 pg/ml.